Instead, he put it out of play _ over the left field fence and into the Anaheim Angels bullpen.
The two-run homer by the hot-hitting Ramirez with one out in the ninth inning lifted the Cleveland Indians to a 6-5 victory over the Angels on Wednesday, snapping a five-game losing streak.
"The most improbable ending," Indians manager Mike Hargrove said. "Who would have thought Manny Ramirez would hit a two-run homer off Troy Percival, arguably the best closer in the game? He's awfully good."
After Jim Thome's one-out double off the right field fence _ just out of the reach of Garret Anderson _ Ramirez hit his third homer in two days and 27th of the season.
"In that situation, I'm just trying to put the ball in play," said Ramirez, whose two hits in six career at-bats against Percival have both been homers. "I got a good pitch to hit and I hit it out. (The pitch) was in. I got a good swing and the ball just carried."
The blown save was just the fourth in 34 chances for Percival (2-5), who is winless in five career decisions against the Indians with a 7.50 ERA.
The loss was Anaheim's first in 55 games this year in which they led after eight innings. They were victorious in a similar situation Tuesday night when Percival retired the side in order in the ninth with two strikeouts as the Angels won a 5-4 decision.
"I didn't beat myself," Percival said. "They swung the bats and put it out of the ballpark. I didn't get the ball where I wanted it to go and (Ramirez) hit it."
Tim Salmon's two-out, solo homer in the seventh off Paul Shuey (4-1) had given the Angels a 5-4 lead. Salmon has six homers in his last 10 games, and eight homers in nine games against the Indians this year.
Shuey allowed two hits and the one run in two innings. After the Angels put runners on first and third with two outs in the ninth off Mike Jackson, Paul Assenmacher relieved and walked Jim Edmonds before retiring Dave Hollins on a popup to third to end the game.
Jackson has 27 saves, but has blown his last three chances. The save was the first for Assenmacher since last Sept. 19.
"Given the circumstances, I thought we were justified in going to Assenmacher," Hargrove said. "If we had won six in a row, I might not have done that. We had lost five in a row."
Hollins hit a two-run double in the third off Bartolo Colon to give the Angels a 3-1 lead, and a solo homer off Colon to open the sixth, tying the game 4-4.
Kenny Lofton had two hits and two RBIs for the Indians, who scored three runs in the top of the sixth off Omar Olivares to take a 4-3 lead.
Olivares, who has lost six straight decisions since June 17, allowed four runs and eight hits in 5 2-3 innings. Colon gave up four runs and eight hits in six innings.
After the game, the Angels designated first baseman Cecil Fielder for assignment and activated first baseman-outfielder Todd Greene.
Notes: Ramirez has driven in 32 runs in his last 25 games to give him a total of 95 this season. ... Anderson has hit in four straight games since his 28-game hitting streak _ longest in the majors this year _ came to an end last Saturday. ... The game was played before a sellout crowd of 43,104 on Disneyland Employee Day. It was the Angels' sixth home sellout of the season. ... Angels first baseman-outfielder Darin Erstad, hitting .303 with 19 homers and 68 RBIs, sat out his second straight game because of a slightly strained left hamstring. ... Salmon, bothered by an injured right foot nearly all season, hit his first triple of the year in the third. It was a fly ball off the right field fence that bounced away from Ramirez. ... Angels right-hander Ken Hill, sidelined since undergoing arthroscopic surgery on his pitching elbow June 15, threw 45 pitches with no discomfort in a simulated game Wednesday morning, the team said. Hill, 8-5 with a 5.15 ERA, is scheduled to make a rehabilitation start Sunday for Cedar Rapids of the Class A Midwest League.