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RALEIGH, N.C. -- Daniel Coursey scored 17 points and Mercer pulled off the biggest upset in the NCAA Tournament so far by knocking off Duke 78-71.
Jakob Gollon added 20 points for the 14th-seeded Bears (27-8).
The Atlantic Sun champions -- the same league that produced 2013 tournament darling Florida Gulf Coast -- shot 56 percent.
The Bears were simply too much for a Duke team with stars Jabari Parker and Rodney Hood.
Mercer scored 11 straight points during the late 20-5 run that clinched the biggest victory in school history. It's the second one-and-done in three years for the third-seeded Blue Devils.
No. 2 Kansas 80, No. 15 Eastern Kentucky 69
ST. LOUIS -- Andrew Wiggins scored 19 points, Jamari Traylor and Perry Ellis had double-doubles and second-seeded Kansas pulled away down the stretch to beat pesky Eastern Kentucky 80-69 on Friday in the second round of the NCAA Tournament.
Traylor finished with 17 points and 14 rebounds, and Ellis had 14 points and 13 boards for the Jayhawks (25-9), who trailed 56-53 with 9 minutes to go before their game-ending charge.
They advanced to play No. 10 seed Stanford, a 58-53 winner over seventh-seeded New Mexico, on Sunday in the third round of the South Regional.
No. 1 Arizona 68, No. 16 Weber St. 59
SAN DIEGO -- Nick Johnson scored 18 points, Aaron Gordon added 16 and top-seeded Arizona overcame a shaky start and a late run by Weber State to beat the Wildcats 68-59 in the NCAA Tournament's West Regional on Friday.
Arizona (31-4) fell into an eight-point hole in the opening minutes to give the 16th-seeded Wildcats hope of a monumental upset.
The desert Wildcats tried to squash the dream quickly with two big second-half runs, but Weber State fought its way back from a 21-point deficit to make it close in the second half.
No. 6 Baylor 74, No. 11 Nebraska 60
SAN ANTONIO -- Cory Jefferson scored 16 points and No. 6 seed Baylor kept 11th-seeded Nebraska winless in its NCAA Tournament history with a 74-60 second-round victory Friday.
The Bears (25-11) kept up a two-month tear and will play either No. 3 seed Creighton or No. 14 seed Louisiana-Lafayette on Sunday. Baylor has won 11-of-13 after a dismal start in the Big 12, recapturing the kind of momentum that vaulted the Bears to the Elite Eight in 2010 and 2012.
No. 3 Creighton 76, No. 14 Louisiana-Lafayette 66
SAN ANTONIO -- Doug McDermott scored in bunches and Ethan Wragge delivered the critical 3-pointers. Together they kept Creighton marching on, right back where they'd promised they'd be.
McDermott scored 30 points and Wragge made three huge momentum-changing shots in the second half, sending No. 3 seed Creighton to a tough 76-66 win over No. 14 Louisiana-Lafayette on Friday in the West Regional.
And with the win, the Bluejays advance to the third round the NCAA Tournament, the very spot they've been forced out the last two years.
No. 10 Stanford 58, No. 7 New Mexico 53
ST. LOUIS -- Chasson Randle scored 23 points and No. 10 seed Stanford made an impression in its first NCAA appearance since 2008, leading almost start to finish in a 58-53 victory over seventh-seeded New Mexico on Friday.
The Cardinal (22-12) built an early 16-point lead then held on after New Mexico rallied to tie it midway through the second half. They got four crucial free throws from reserve Robbie Lemons and Randle in the final half-minute after New Mexico had cut the deficit to two points. They will play the Eastern Kentucky-Kansas winner on Sunday in the third round.
No. 11 Tennessee 86, No. 6 Massachusetts 67
RALEIGH, N.C. -- Jarnell Stokes scored a career-high 26 points and grabbed 14 rebounds to help Tennessee beat Massachusetts 86-67 on Friday in the second round of the NCAA Tournament.
Jordan McRae added 21 points for the Volunteers (23-12), the No. 11 seed in the Midwest Regional. Tennessee had little trouble with the sixth-seeded Minutemen (24-9), shooting 54 percent from the field.
No. 6 North Carolina 79, No. 11 Providence 77
SAN ANTONIO -- James Michael McAdoo sank two free throws in the final 3.5 seconds, and No. 6 seed North Carolina rallied to beat 11th-seeded Providence 79-77 Friday night.
Providence's Bryce Cotton scored a career-high 36 points and made one dazzling shot after another down the stretch. But he also fumbled a long rebound in the final moments, robbing the Friars of a chance for a last-second miracle.
Had North Carolina (24-9) lost, it would've been the first time since 1979 the Tar Heels and rival Duke lost on the same day of the tournament.
No. 1 Wichita State 64, No. 16 Cal Poly 37
ST. LOUIS -- Cleananthony Early had 23 points and unbeaten Wichita State faced no resistance from Cal Poly, going to 35-0 for the best start in NCAA history with a 64-37 rout of Cal Poly in the Midwest Region on Friday night.
The Shockers (35-0) dominated from the tip-off against the only team with a sub-.500 record in the tournament. With the exception of Early, most of the glaring numbers were on defense. The losers managed 13 points in the first half and shot 21 percent.