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By Barry Wilner | Associated Press
San Francisco (1-4) at Buffalo (3-2), 1 p.m.
With Colin Kaepernick now the starter, he's going to attract attention for more than his refusal to stand during the national anthem. It took a four-game slide with Blaine Gabbert showing little at quarterback for coach Chip Kelly to make the change. Buffalo is hoping to keep streaking after going 3-0 since elevating Anthony Lynn to offensive coordinator and firing Greg Roman.
Cincinnati 2-3) at New England (4-1), 1 p.m.
Tom Brady's first regular-season game in Foxborough after serving his four-game "Deflategate" suspension -- and look for Brady to fill the air with regulation footballs. The Bengals were humiliated in Dallas, and they haven't won in New England in 30 years. Brady is 5-1 against them with 12 TDs and a 101.2 passer rating.
Philadelphia (3-1) at Washington (3-2), 1 p.m. (FOX)
Philly stumbled at Detroit after losing its momentum from a 3-0 start by having an early bye. Rookie quarterback Carson Wentz has been terrific, but it's the Eagles' defensive performance that has been just as crucial. Washington dropped its first two games, but Kirk Cousins throwing to DeSean Jackson, Pierre Garcon, Jamison Crowder and Jordan Reed has sparked the attack.
Pittsburgh (4-1) at Miami (1-4), 1 p.m.
For Miami, which has been awful with the ball, struggles to protect Ryan Tannehill, and is a minus-7 in turnover margin; only the Jets are worse. Ben Roethlisberger leads the league with 15 touchdown passes, the most through five games in Steelers history, and WR Antonio Brown is tops with 37 catches.
Baltimore (3-2) at New York Giants (2-3), 1 p.m.
Unlike their AFC North brethren, the Ravens have stalled on offense, leading to the firing this week of coordinator Marc Trestman. Odell Beckham Jr. finally got into the end zone last week at Green Bay, but that didn't do much for New York, which has dropped three in a row. New York is minus-7 in turnover differential, with only three takeaways.
Los Angeles (3-2) at Detroit (2-3), 1 p.m.
To get to .500, Detroit will need to figure out Todd Gurley. The 2015 Offensive Rookie of the Year went for 140 yards on 16 carries and had two TDs in last year's win over the Lions in St. Louis. Gurley has yet to break out this season, though, with only a 2.7-yard average. But he has rushed for three scores.
Jacksonville (1-3) at Chicago (1-4), 1 p.m.
The Jaguars are 4-21 on the road in coach Gus Bradley's four seasons, including 0-6 against NFC teams. The Bears have gotten good enough play from backup QB Brian Hoyer -- three straight 300-yard games, six TDs, no picks -- that Jay Cutler might not get back his job once fully healthy.
Carolina (1-4) at New Orleans (1-3), 1 p.m.
Carolina's chances of winning a fourth consecutive NFC South are fading after losing their first two division matchups. A third one could be devastating. As always, New Orleans' chances ride on Brees' arm. He seems more comfortable every week with his current group of targets: Brandin Cooks, Willie Snead, Coby Fleener and rookie Michael Thomas.
Cleveland (0-5) at Tennessee (2-3), 1 p.m. (CBS)
The Titans can run the ball, with DeMarco Murray second in the NFL with 461 yards rushing and 633 yards from scrimmage. Murray leads everyone with 33 first downs. Cleveland is gutsy, but so banged up. The Browns believe this is a good opportunity to get off the schneid, but they'll need to figure out how to close out a victory if they get in position.
Kansas City (2-2) at Oakland (4-1), 4:05 p.m.
The Chiefs have won three straight vs. Oakland and six straight within the division. Alex Smith loves seeing the Raiders on the other side of the line of scrimmage: He's 7-1 with 18 TDs, three interceptions and a 106.1 passer rating in this matchup.
Dallas (4-1) at Green Bay (3-2), 4:25 p.m. (FOX)
The way Dak Prescott is throwing it (155 passes without a pick) and Ezekiel Elliott is running it (league-high 546 yards), Dallas is proving you can win behind rookies . Still, the Packers hold opponents to 42.8 yards rushing per game. If the Cowboys, 4-11 at the Packers, come close to their 155.2 yards per game on the ground, it will be impressive.
Atlanta (4-1) at Seattle (3-1), 4:25 p.m.
Ryan leads the NFL with a 121.6 passer rating, and Julio Jones has averaged a phenomenal 21.5 yards a catch. This is a matchup of the Falcons' No. 1-ranked offense against the Seahawks' top-ranked defense. Very juicy indeed.
Indianapolis (2-3) at Houston (3-2), 8:30 p.m. (WKYC)
The Colts are 23-5 against Houston, and Andrew Luck has won 14 of his past 15 starts within the division. He might need a big game because Indy is not likely to shut down receivers DeAndre Hopkins, Jaelen Strong and rookie Will Fuller.
N.Y. Jets (1-4) at Arizona (2-3), 8:30 p.m. (ESPN)
The Jets' crucible of five 2015 playoff teams in six weeks ends here. It hasn't been pretty, and with Carson Palmer expected back from his concussion, the Cardinals will be a difficult opponent. But Arizona also has lost both starting guards, Mike Iupati and Evan Mathis, and New York has a good defensive line.
BYES: Tampa Bay (2-3), Minnesota (5-0).